Vascular-targeted micelles as a specific MRI contrast agent for molecular imaging of fibrin clots and cancer cells

Molecular medical imaging is intended to increase the accuracy of diagnosis, particularly in cardiovascular and cancer-related diseases, where early detection could significantly treatment success rate. In this study, we present mixed micelles formed from four building blocks as a magnetic resonance targeted contrast agent for atheroma cancer cells. The are gadolinium-loaded DOTA ring responsible enhancement, fibrin-specific CREKA pentapeptide targeting, fluorescent dye DSPE-PEG2000. were fully characterized terms their size, zeta potential, stability, relaxivity toxicity. Target binding assays performed on fibrin clots quantified by fluorescence image signal intensities proved power. An additional internalization assay showed that also designed specifically enter into Overall, these multimodal represent potential formulation MRI molecular